Which sequence best describes the progression of the basic pathophysiology of metabolic syndrome?

Which sequence best describes the progression of the basic pathophysiology of metabolic syndrome?

• A. Hyperinsulinemia and obesity lead to endothelial dysfunction and inflammation, promoting ASCVD and hyperglycemia
• B. Endothelial dysfunction occurs independently of obesity
• C. Endothelial health improves with weight loss
• D. Non-inflammatory processes drive ASCVD

Answer: (A)